Program, 19th International Conference on Cytochrome P450, Tokyo, 2015

Program

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Timetable
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Hall A International Conference Room 1F June 12(Fri.)

PL-1:New Aspects of Cytochrome P450 Oxidations of Steroids and Vitamins

PL-1C PL-1
Chair: Hiroshi Yamazaki (Drug Metab and Pharmacokinet, Showa Pharmaceutical University) Speaker:F. Peter Guengerich (1Department of Biochemistry, Vanderbilt University School of Medicine )


Hall A International Conference Room 1F June 13(Sat.)

Session1:P450 Gene Regulation

Session03C Session03-1
Chair:Ken-ichiro Morohashi (Graduate School of Medical Sciences, Kyushu University ) Chair:Masahiko Negishi (Reproductive Developmental Biology Laboratory, National Institute of Enviromental Health Sciences, NIH)
Session01-1 Session01-2
Speaker1:Miki Nakajima (Drug Metabolism and Toxicology, Kanazawa University)
Title:microRNAs regulating P450 expression and activities: perspective for future medicine

Speaker2:Bon-Chu Chung (Institute of Molecular Biology, Academia Sinica )
Title:Regulation and Functions of Steroid Hydroxylase P450scc (CYP11A1)

Session01-3 Session01-4
Speaker3:Albert Braeuning (Institute of Experimental and clinical Pharmacology and Toxicology, Department of Toxicology, University of Tuebingen)
Title:Regulation of hepatic cytochrome P450 expression by Wnt/β-catenin signaling
Speaker4:Kouichi Yoshinari (School of Pharmaceutical Sciences, University of Shizuoka )
Title:Regulation of CYP3A gene expression by sterol-responsive transcription factors

 

PL-2:Structural determinants of P450 mediated human drug metabolism: A moving target

Session04-4 PL-2
Chair:Shingo Nagano(Department of Chemistry and Biotechnology, Graduate School of Engineering, Tottori University) Speaker:Eric Johnson (Molecular & Experimental Medicine - 255, The Scripps Research Institute )

 

Session3:P450 Biology

Session01-4 Session03-3
Chair:Kouichi Yoshinari (School of Pharmaceutical Sciences, University of Shizuoka ) Chair:Marion Sewer (School of pharmacy ,University of California Sandiego )
Session03-1 Session03-2

Speaker1:Masahiko Negishi (Reproductive Developmental Biology Laboratory, National Institute of Enviromental Health Sciences,NIH)
Title:BIOLOGY OF NUCLEAR RECEPTORS CAR AND PXR AS CELL SIGNAL TRANSDUCING SCAFFOLDS

Speaker2:John Chiang (Integrative Medical Sciences, Northeast Ohio Medical University )
Title:CYP7A1 and bile acid signalling in hepatic lipid metabolism and disease

Session03-3 Session03-4
Speaker3:Marion Sewer (School of pharmacy ,University of California San Diego )
Title:Signaling Pathways Regulating Steroid Hydroxylase Gene Transcription
Speaker4:Takashi Baba (Molecular Biology, Kyushu University )
Title:Nuclear receptor and metabolism

 

Session5:P450 and Transporter Interplay

Session05-3 Session05-4
Chair:Ikumi Tamai (Faculty of Pharmaceutical Sciences, Institute of Medical Pharmaceutical and Health Sciences, Kanazawa University ) Chair:Richard Kim (Medicine, Western University )
Session05-3 Session05-4
Speaker1:Ikumi Tamai (Faculty of Pharmaceutical Sciences, Institute of Medical Pharmaceutical and Health
Sciences, Kanazawa University )
Title: Quantitative Prediction of Hepatic Disposition of Drugs and Metabolites by In Vitro Sandwich-cultured Hepatocytes and by In Vivo Biomarker
Speaker2:Richard Kim (Medicine, Western University )
Tentative topic title:P450-Transporter Interplay
Session05-1 Session05-2
Speaker3:Ichiro Ieiri (Clinical Pharmacokinetics, Kyushu University)
Title:Methods for testing contributions of drug metabolizing enzymes and transporters to the pharmacokinetic profile of a drug
Speaker4:Amin Rostami-Hodjegan (Faculty of Medical and Human Sciences, University of Manchester & Certara )
Title:Creating "Realistic" Virtual Patients for Purpose of Drug Development: The Importance of Inter-Correlations between Enzyme and Transpoter Abundances

 

Hall B 1st Meeting Room 2F June 13(Sat.)

Session2:Non-P450 Oxygenase

Session02C  
Chair:Yoshitsugu Shiro(RIKEN SPring -8 Center)  
Session02-1 Session02-2

Speaker1:Shinobu Itoh(Graduate School of Engineering, Osaka University)
Title:Models for Active Oxygen Intermediates of Copper Monooxygenases

Speaker2:Amy C. Rosenzweig (Departments of Molecular Biosciences and of Chemistry, Northwestern University)
Title:Particulate methane monooxygenase
Session02-3 Session02-4
Speaker3:Masahito Kodera (Department of Molecular Chemistry and Biochemistry, Doshisha University )
Tentative topic title:Highly reactive anti-dioxo high-spin diiron(IV)
Speaker4:Syun-Ru Yeh (Physiology and Biophysics, Albert Einstein College of Medicine )
Tentative topic title:TRYPTOPHAN DIOXYGENATION BY HEME-BASED DIOXYGENASES: FROM STRUCTURE TO FUNCTION

 

Luncheon Seminar 1:Human P450 research with hepatic cells

Speaker:Hiroshi Yamazaki (Drug Metab and Pharmacokinet, Showa Pharmaceutical University )

 

 

Session4:P450 Structures

Session04-4 Session04-2
Chair:Shingo Nagano(Department of Chemistry and Biotechnology, Tottori University ) Chair: Larissa Podust(Skaggs School of Pharmacy and Pharmaceutical Sciences, UCSD )
Session04-1 Session04-4

Speaker1:Emily Scott (Department of Medicinal Chemistry,University of Kansas )
Title:Structure, Function, and Inhibition of Steroidogenic Human Cytochrome P450 17A1

Speaker2:Shingo Nagano(Department of Chemistry and Biotechnology, Tottori University)
Title: Crystal structure of CYP90B1, which is involved in brassinosteroid biosynthesis

Session04-3 Session04-2
Speaker3:James Halpert (School of Pharmacy, University of Connecticut )
Title: Structural Plasticity of Human, Rabbit, and Rodent CYP2B Enzymes: Role in Species Differences
Speaker4:Larissa M. Podust(Skaggs School of Pharmacy and Pharmaceutical Sciences, UCSD )
Tentative topic title:Structure-Aided Drug Discovery Targeting CYP51

 

 

Session6:Heme Chemistry

Session06C Session06C2
Chair:Masao Ikeda-Saito (Tohoku University ) Chair:John H.Dawson (University of South Carolina )
Session06-1 Session06-2

Speaker1:C.S.Raman (University of Maryland)
Title:Peering into the exaptations of ohnologous cytochromes P450

Speaker2:Emma Raven(Chemistry, University of Leicester )
Title:The nature of ferryl heme

Session06-3 Session06-4
Speaker3:Thomas Poulos (Departments of Molecular Biology and Biochemistry, Pharmaceutical Sciences, and Chemistry, University of California, Irvine)
Title:The Role of Redox Partner Binding in P450 Conformational Dynamics
Speaker4:Wonwoo Nam (Department of Chemistry, Ewha Womans University )
Title:Biomimetic Metal-Oxygen Intermediates in Dioxygen Activation Chemistry

 

Hall A International Conference Room 1F June 14(Sun.)

Session7:P450-Dependent Drug Metabolism

Session07C  
Chair:Yoichi Naritomi (Astellas Pharma Inc. )  
Session07-1 Session07-2

Speaker1:Amit Kalgutkar(Pharmacokinetics, Dynamics and Metabolism Department,Pfizer Inc. )
Title: Mitigating Idiosyncratic Toxicity Risks with the N1-substituted-6-arylthiouracils Class of Myeloperoxidase Inactivators: Identification of a Clinical Candidate to Treat Cardiovascular Diseases

Speaker2:R. Scott Obach (Pharmacokinetics, Pharmacodynamics, and Drug Metabolism,Pfizer Inc. )
Title:CYTOCHROME 450 ENZYMES IN THE HUNT FOR ACTIVE METABOLITES

Session07-3 Session07-4
Speaker3:Tamihide Matsunaga (Department of Clinical Pharmacy, Graduate School of Pharmaceutical Sciences, Nagoya City University )
Title:Utility of iPS Cells for Study of Drug Metabolism and Pharmacokinetics: Differentiation of human iPS cells into hepatocytes and enterocytes
Speaker4:Frank Gonzalez (Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, NIH)
Title:The use of xenobiotic receptor and P450 humanized mice in elucidating the mechanisms of drug-induced toxicity

 

PL-3:Drug Metabolism Contributions to the Development of Precision Medicine

PL-1C PL-3
Chair:Hiroshi Yamazaki(Drug Metab and Pharmacokinet, Showa Pharmaceutical University) Speaker:Allan Rettie (Departments of Medicinal Chemistry, School of Pharmacy, University of Washington )

 

Session9:Drug Protein Binding and Idiosyncratic Drug Reactions

Session09-1 Session09C
Chair:Jack Uetrecht (Pharmaceutical Sciences, University of Toronto ) Chair:Raku Shinkyo (Eisai Co., Ltd. )
Session09-1 Session09-2

Speaker1:Jack Uetrecht (Pharmaceutical Sciences, University of Toronto )
Title:How do reactive metabolites lead to the immune response that can lead to an idiosyncratic drug reaction?

Speaker2:Dean J. Naisbitt (MRC Centre for Drug Safety Science, the Department of Molecular and Clinical Pharmacology, The University of Liverpool)
Title: The role of drug and drug metabolite-specific T-cells in immunological drugs reactions targeting liver and skin
Session09-3 Session09-4
Speaker3:Gerry Kenna(FRAME Office, FRAME)
Title: Integrating metabolic bioactivation alongside other adverse properties to predict and avoid human adverse drug reactions
Speaker4:Hideo Takakusa (Drug Metabolism & Pharmacokinetics Resarch Laboratories,Daiichi Sankyo Co.,Ltd. )
Title: Risk Assessment of Chemically Reactive Metabolites and Idiosyncratic Drug Toxicity in Drug Discovery and Development

 

Session11:Drug Interaction

Session11-4 Session11-3
Chair:Yoshiro Saito (Medicinal Safety Science, National Institute of Health Sciences ) Chair:Kiyomi Ito (Research Institute of Pharmaceutical Sciences, Musashino University)
Session11-3 Session11-4

Speaker1:Kiyomi Ito (Research Institute of Pharmaceutical Sciences, Musashino University)
Title:Use of modeling and simulation for the prediction of drug interactions

Speaker2:Yoshiro Saito (Medicinal Safety Science, National Institute of Health Sciences )
Title:Japanese final draft guideline on drug interaction studies for drug development and labeling recommendations
Session11-1 Session11-2
Speaker3:Lei Zhang (USA )
Tentative topic title:A Scientific Perspective on Drug Interaction Evaluation in Drug Development

Speaker4:Andrew Parkinson (CYP450, XPD Consulting )
Title: The practical aspects of complying with regulatory guidelines on drug interactions: Some notable strengths and weaknesses of in vitro testing

 

Hall B 1st Meeting Room 2F June 14(Sun.)

Session8:Mechanism of P450

Session08C  
Chair:Yoshihito Watanabe (Department of Chemistry, Graduate School of Science,Nagoya University )  
Session08-1 Session08-3

Speaker1:Michael T. Green (Chemistry,Penn State University )
Title: Cytochrome P450 Oxidations: A Controlled Burn of Inert Organic Compounds

Speaker2:Willem Koppenol (Department of Chemistry and Applied Biosciences, Swiss Federal Institute of Technology (ETH) )
Title: In search of Compound I of cytochrome P450
Session08-2 Session08-4

Speaker3:John T. Groves (Department of Chemistry, Princeton University)
Title:Aromatic Peroxygenases: Novel Heme-thiolate P450 Analogs

Speaker4:Paul Ortiz de Montellano (Pharmaceutical Chemistry, University Of California, San Francisco )
Title: Ligand-Dependent Conformational Dynamics of CYP119 by Two-Dimensional NMR and X-Ray Crystallography

 

Luncheon Seminar 2:A new era of humanized mouse models ---Humanized liver model based on super immunodeficient NOG mouse---

Speaker:Hiroshi Suemizu (Central Institute for Experimental Animals (CIEA))  

 

Session10:Steroid-Metabolizing P450s

Session10-2 Session10-3
Chair:Nobuhiro Harada (Department of Biochemistry,Fujita Health University School of Medicine ) Chair:Takeshi Yamazaki (Graduate School of Integrated Arts and Sciences, Hiroshima University )
Session10-1  
Introduction of the session:Yuri Aoyama(Department Bioinformatics Faculty of Engineering ,Soka University )  
Session10-5 Session10-3
Speaker1:David J. Waxman(Department of Biology and Bioinformatics Program, Boston University)
Title: Liver steroid-metabolizing P450s: Sex and hormone-dependent genomic and epigenetic regulatory mechanisms
Speaker2:Takeshi Yamazaki (Graduate School of Integrated Arts and Sciences, Hiroshima University )
Title:De novo synthesis and conversion of neuroprotective steroids by brain P450
Session10-2 Session10-4
Speaker3: Nobuhiro Harada (Department of Biochemistry,Fujita Health University School of Medicine )
Title: Rapid dual regulation of cyp19A1 (P450arom) in nerve cells as neuroestrogen synthase
Speaker4:Stephen Sligar (School of Molecular and Cellular Biology ,University of Illinois )
Title:The Molecular Mechanisms of Cytochrome P450: What's Next?

 

 

Session12:P450s and Drug Design

Session12-3  
Chair:Toshiyuki Sakaki (Department of Biotechnology, Toyama Prefectural University )  
Session12-2 Session12-1
Speaker1:Sergey A. USANOV (Protein Engineering, Institute of Bioorganic Chemistry, National Academy of Science of Belarus)
Title: STRUCTURE AND FUNCTION OF ENZYMES FOR CHOLESTEROL DERIVATIVES BIOSYNTHESIS AND METABOLISM
Speaker2:Galina Lepesheva (Biochemistry, Vanderbilt University School of Medicine )
Title:CYP51 structure-based VNI scaffold development for treatment of human infections: Trypanosomatidae vs. the filamentous fungus Aspergillus fumigatus
Session12-4 Session12-3
Speaker3:Barry V. L. Potter (Pharmacology ,University of Oxford )
Title: Dual Aromatase-Sulfatase Inhibitors as a Multi-Targeting Strategy in Drug Design
Speaker4:Toshiyuki Sakaki (Department of Biotechnology, Toyama Prefectural University )
Title:CYP24A1 is a key enzyme to develop vitamin D analogs as anti-osteoporosis or anti-cancer drugs

 

Hall A International Conference Room 1F June 15(Mon.)

Session13:In silico PBPK Modeling &Simulation of P450s

Session13-3 Session13-1
Chair:Koji Chiba (Laboratory of Clinical Pharmacology, Yokohama University of Pharmacy ) Chair:Aleksandra Galetin (Centre for Applied Pharmacokinetic Research, Manchester Pharmacy School, University of Manchester)
Session13-1 Session13-2
Speaker1:Aleksandra Galetin (Centre for Applied Pharmacokinetic Research, Manchester Pharmacy School, University of Manchester)
Title:MODELLING AND SIMULATION OF TRANSPORTER-METABOLISM INTERPLAY AND CORRESPONDING DRUG-DRUG INTERACTIONS

Speaker2:Yuichi Sugiyama(Sugiyama Laboratory, RIKEN Innovation Center, RIKEN)
Title: Kinetic interpretation of complex drug-drug interaction on both P450s and membrane transporters: Importance of knowing rate-determining process

Session13-3 Session13-4
Speaker3:Koji Chiba (Laboratory of Clinical Pharmacology, Yokohama University of Pharmacy )
Title:Variability of P450 activity for prediction of drug exposure in human
Speaker4:Akihiro Hisaka (Geriatric Pharmacolgy and Therapeatics, Graduate School of Pharmaceutical Sciences, Chiba University)
Title:Evaluation and Modeling of Intestinal Contribution in Pharmacokinetics

 

PL-4:IVIVE within PBPK for P450: The Move from Ranking to Quantitative Prediction of Clearance

Session13-3 Session05-2
Chair:Koji Chiba (Laboratory of Clinical Pharmacology, Yokohama University of Pharmacy ) Speaker:Amin Rostami-Hodjegan (Faculty of Medical and Human Sciences, University of Manchester & Certara )

 

Session15:P450-Protein Interactions

Session15-1 Session15-4
Chair:Amit Pandey (Pediatric endocrinology , University Children's Hospital Bern ) Chair:Yuji Ishii(Graduate School of Pharmaceutical Sciences, Kyushu University )
Session15-1 Session15-3
Speaker1:Amit Pandey (Pediatric endocrinology , University Children's Hospital Bern )
Title:Interactions of Cytochrome P450 Reductase (POR) and Cytochrome b5 with P450 : Impact on Sex, Drugs and Metabolic Disorders
Speaker2:Colin Henderson (Medical Research Institute,University of Dundee )
Title: Defining the interaction of cytochrome b5 with human cytochrome P450s in vivo
Session15-2 Session15-4
Speaker3:Wayne Backes (Department of Pharmacology , Louisiana State University Health Sciences Center )
Title: The Role of the Lipid Membrane in the Localization of P450 System Proteins in the Endoplasmic Reticulum
Speaker4:Yuji Ishii(Graduate School of Pharmaceutical Sciences, Kyushu University )
Title: Domains of UDP-glucuronosyltransferase serve in the functional interaction with cytochrome P450 3A4

 

Session14:Novel P450s and Reactions

Session14C1 Session14C2
Chair:Rita Bernhardt (Institut für Biochemie, Universität des Saarlandes ) Chair:Hirofumi Ichinose (Faculty of Agriculture, Kyushu University )
Session14-4 Session14-1
Speaker1:Max J. Cryle (Department of Biomolecular Mechanisms, Max Planck Institute for Medical Research )
Title: The curious and crucial role of P450s in glycopeptide antibiotic biosynthesis
Speaker2:Vlada B. Urlacher(Institute of Biochemistry, Heinrich-Heine University Düsseldorf)
Title:Chemo-, regio- and stereoselective oxidation of terpenoid scaffolds by cytochrome P450 enzymes
Session14-2 Session14-3
Speaker3:Neil Bruce (Department of Biology, University of York )
Title:Biodegradation of the explosive RDX by the cytochrome P450 system XplA/B
Speaker4:Yogan Khatri (Department of Biochemistry, Saarland University )
Title:Deorphanization of novel myxobacterial cytochromes P450: A leap for potential industrial and pharmaceutical applications

 

Luncheon Seminar 3:Cytochrome P450 : Significance in development of new drugs

Speaker:Kazuhide Iwasaki (Pharmacokinetics and Bioanalysis Center, Shin Nippon Biomedical Laboratories, Ltd. )  

 

Session16:Nanotechnology and Biophysics of P450

Session16-4  
Chair:Osami Shoji (Department of Chemistry, Graduate School of Science,Nagoya University )  
Session16-1 Session16-2
Speaker1:Rudi Fasan (Department of Chemistry, University of Rochester )
Title:P450-catalyzed C(sp3)-H amination reactions
Speaker2:Elizabeth Gillam (School of Chemistry and Molecular Biosciences, The University of Queensland )
Title: Artificial Evolution of a Novel, Thermostable, Promiscuous, Drug-Metabolizing P450
Session16-3 Session16-4
Speaker3:Andrew Munro (Manchester Institute of Biotechnology, Faculty of Life Sciences, The University of Manchester )
Title:A novel P450 catalyst for pravastatin production
Speaker4:Osami Shoji (Department of Chemistry, Graduate School of Science,Nagoya University )
Title: Hydroxylation of Gaseous Alkanes Catalyzed by Wild-type Cytochrome P450BM3 Assisted by the Next Generation of Decoy Molecules

 

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